
Axe 1. Cellules stromales et myéloïdes dans la cicatrisation osseuse.
Pierre Layrolle (DR Inserm), Philippe Rosset (PU-PH, Chirurgien orthopédiste, CHU Tours)
Alain HOORNAERT (MCU-PH)
Post-doctorant : Meadhbh Brennan (PARAGEN, Marie Curie Fellow, Harvard Medical School, USA)
Doctorants : Luciano Vidal (régénération de grands défauts osseux)
Walid Lakhal (régénération os/ligaments articulaires)
Paul Humbert (biomarqueurs de la cicatrisation osseuse)
Ingénieurs et techniciens : Bénédicte Brulin (IE Inserm), Julien de Lima (AI CDD Inserm)
Manager projets européens : Solenne Lhéritier
lien pour les essais cliniques REBORNE
lien pour le projet H2020 ORTHOUNION ou ici
lien pour le projet MSCA PARAGEN
lien pour le projet H2020 MAXIBONE
lien vers la Ligue Française contre la neurofibromatose
PHRC MOCASO : Aide à la consolidation des fractures des os longs par association de moelle osseuse concentrée autologue et de substitut osseux (30 patients)
Principales publications récentes :
- Gjerde C, Mustafa K, Hellem S, Rojewski M, Gjengedal H, Yassin MA, Feng X, Skaale S, Berge T, Rosen A, Shi XQ, Ahmed AB, Gjertsen BT, Schrezenmeier H, Layrolle P. Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Res Ther. 2018;9:213
- Gómez-Barrena E, Rosset P, Gebhard F, Hernigou P, Baldini N, Rouard H, Sensebé L, Gonzalo-Daganzo RM, Giordano R, Padilla-Eguiluz N, García-Rey E, Cordero-Ampuero J, Rubio-Suárez JC, Stanovici J, Ehrnthaller C, Huber-Lang M, Flouzat-Lachaniette CH, Chevallier N, Donati DM, Ciapetti G, Fleury S, Fernandez MN, Cabrera JR, Avendaño-Solá C, Montemurro T, Panaitescu C, Veronesi E, Rojewski MT, Lotfi R, Dominici M, Schrezenmeier H, Layrolle P. Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial. Biomaterials. 2018 S0142-9612 30205-9
- Brennan MA, Renaud A, Guilloton F, Mebarki M, Trichet V, Sensebé L, Deschaseaux F, Chevallier N, Layrolle P. Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue-Compared with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions. Stem Cells Transl Med. 2017;6:2160-2172.
- Stanovici J, Le Nail LR, Brennan MA, Vidal L, Trichet V, Rosset P, Layrolle P. Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery. Curr Res Transl Med. 2016;64(2):83-90.
- Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F. Oncostatin M, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 185:765-75, 2015.
- Gamblin AL, Brennan MA, Renaud A, Yagita H, Lézot F, Heymann D, Trichet V, Layrolle P. Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: the local implication of osteoclasts and macrophages. Biomaterials. 2014;35(36):9660-7.
- Brennan MÁ, Renaud A, Amiaud J, Rojewski MT, Schrezenmeier H, Heymann D, Trichet V, Layrolle P. Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate. Stem Cell Res Ther. 2014;5(5):114.
- Gamblin AL, Renaud A, Charrier C, Hulin P, Louarn G, Heymann D, Trichet V, Layrolle P. Osteoblastic and osteoclastic differentiation of human mesenchymal stem cells and monocytes in a miniaturized three-dimensional culture with mineral granules. Acta Biomater. 2014;10(12):5139-47.
- Rosset P, Deschaseaux F, Layrolle P. Cell therapy for bone repair. Orthop Traumatol Surg Res. 2014;100(1 Suppl):S107-12.
- Guihard P, Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F. Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling. Stem Cells. 2012;30(4):762-72.