
Axe 2. Cellules myéloïdes et stromales dans l'inflammation chronique.
Frédéric Blanchard (DR Inserm), Benoit Le Goff (PU-PH, rhumatologiste)
Christelle Darrieutort (PH, rhumatologiste), Jean-Marie Berthelot (PH, rhumatologiste)
Ingénieur : Julien de Lima (IE CDD Univ)
Master 2 : Allan Avenel, Adrien Lepluart
- Projet 1 : Rôle et mécanisme d'action de nouvelles cytokines anti-inflammatoires de la famille de l'IL-1 dans les arthrites inflammatoires.
Lire l'article sur le site de l'Inserm.
- Projet 2 : Etude de la membrane synoviale dans la polyarthrite rhumatoïde. Intérêt diagnostique, prognostique et nouvelles thérapies ciblées.
- Projet 3 : Pathogenèse et inflammation de la tendinopathie calcifiante.
Lire l'article dans Ann Rheum Dis.
Principales publications récentes :
- Najm A, Masson FM, Preuss P, Georges S, Ory B, Quillard T, Sood S, Goodyear CS, Veale DJ, Fearon U, Le Goff B, Blanchard F. miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol. doi: 10.1002/art.41441.
- Darrieutort-Laffite C, Arnolfo P, Garraud T, Adrait A, Couté Y, Louarn G, V Trichet, Layrolle P, Le Goff B, Blanchard F. Rotator cuff tenocytes differentiate into hypertrophic chondrocyte-like cells to produce calcium deposits in an alkaline phosphatase-dependent manner. J Clin Med. 8:1544, 2019.
- Najm A, Blanchard F, Le Goff B. Micro-RNAs in inflammatory arthritis: from physiopathology to diagnosis, prognosis and therapeutic opportunities. Biochem Pharmacol. 165:134-144, 2019.
- Najm A, le Goff B, Venet G, Garraud T, Amiaud J, Biha N, Charrier C, Touchais S, Crenn V, Blanchard F, Krenn V. IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis. Joint Bone Spine. 86:77-81, 2019.
- Garraud T, Harel M, Boutet MA, Le Goff B, Blanchard F. The enigmatic role of IL-38 in inflammatory diseases. Cytokine Growth Factor Rev. 39: 26-35, 2018.
- Darrieutort-Laffite C, Blanchard F, Le Goff B. Calcific tendonitis of the rotator cuff: From formation to resorption. Joint Bone Spine. 85:687-692, 2018.
- Boutet MA, Najm A, Bart G, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F, Le Goff B. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis, 76:1304-1312, 2017.
- Boutet MA, Bart G, Gahier M, Amiaud J, Brulin B, Charrier C, Morel F, Lecron JC, Rolli-Derkinderen M, Bourreille A, Vigne S, Gabay C, Palmer G, Le Goff B, Blanchard F. Distinct Expression of IL-36a, b, g, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease. Clin Exp Immunol, 184:159-73, 2016.
- Flanagan-Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Sahu S, Haskins M, Blanchard F, Steet R. Cathepsin-Mediated Alterations In TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res, 31:535-48, 2016.
- Bougault C, Briolay A, Boutet MA, Pilet P, Delplace S, Le Goff B, Guicheux J, Blanchard F, Magne D. Wnt5a is expressed in spondyloarthritis and exerts opposite effects on enthesis and bone in murine organ and cell cultures. Transl Research, 166:627-38, 2015.
- Rabeony H, Vasseur P, Pohin M, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F. IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol, 45:2847-57, 2015.
- Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F. Oncostatin M, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 185:765-75, 2015.
- Monderer D, Luseau A, Bellec A, David E, Ponsolle S, Saiagh S, Bercegeay S, Piloquet P, Denis MG, Lodé L, Rédini F, Biger M, Heymann D, Heymann MF, Le Bot R, Gouin F, Blanchard F. New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance. Lab Invest. 93:1100-14, 2013.
- David E, Tirode F, Baud'huin M, Guihard P, Laud K, Delattre O, Heymann MF, Heymann D, Redini F, Blanchard F. Oncostatin M is a growth factor for Ewing sarcoma. Am J Pathol. 181:1782-95, 2012.
- Guihard P, Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F. Induction of osteogenesis in mesenchymal stem cells by activated monocytes / macrophages depends on Oncostatin M signaling. Stem Cells. 30:762-72, 2012.
- Chemel M, Le Goff B, Brion R, Cozic C, Berreur M, Amiaud J, Bougras G, Touchais S, Blanchard F, Heymann MF, Berthelot JM, Verrecchia F, Heymann D. Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. Ann Rheum Dis. 71:150-4, 2012.