PUBLICATIONS DE L UNITE

• Avril P, Vidal L, Barille-Nion S, Le Nail LR, Redini F, Layrolle P, Pinault M, Chevalier S, Perrot P, Trichet V. Epinephrine Infiltration of Adipose Tissue Impacts MCF7 Breast Cancer Cells and Total Lipid Content. Int J Mol Sci. 2019 11;20
• Moukengue B, Amiaud J, Jacques C, Charrier C, Ory B, Lamoureux F. Analysis of mRNA, miRNA, and DNA in Bone Cells by RT-qPCR and In Situ Hybridization. Methods Mol Biol. 2019;1914:169-196.
• Nicolle R; Ayadi M; Gomez-Brouchet A; Armenoult L; Banneau G; Elarouci N; Tallegas M; Decouvelaere AV; Aubert S; Rédini F; Marie B; Labit-Bouvier C; Reina N; Karanian M; le Nail LR; Anract P; Gouin F; Larousserie F; de Reyniès A; de Pinieux G. Grated molecular characterization of chondrosarcoma reveals critical determinants of disease progression. Nat Commun. 2019; 10,4622
• Vargas-Franco JW; Castaneda B; Gama A; Mueller CG; Heymann D; Rédini F; Lézot F. Genetically-achieved disturbances to the expression levels of TNFSF11 receptors modulate the effects of zoledronic acid on growing mouse skeletons. Biochem Pharmacol. 2019;168. 133-148
• Danieau G; Morice S; Rédini F; Verrecchia F; Royer BB. New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies? Int J Mol Sci 2019 .31; 20 15
• Le Caignec C; Ory B; Lamoureux F; O'Donohue MF; Orgebin E; Lindenbaum P; Téletchéa S; Saby M; Hurst A; Nelson K; Gilbert SR; Wilnai Y; Zeitlin L; Segev E; Tesfaye R; Nizon M; Cogne B; Bezieau S; Geoffroy L; Hamel A; Mayrargue E; de Courtivron B; Decock-Giraudaud A; Charrier C; Pichon O; Retière C; Redon R; Pepler A; McWalter K; Da Costa L; Toutain A; Gleizes PE; Baud'huin M; Isidor B. RPL13 Variants Cause Spondyloepimetaphyseal Dysplasia with Severe Short Stature. Am J Hum Genet 2019 in press
• Darrieutort-Laffite C, Arnolfo P, Garraud T, Adrait A, Couté Y, Louarn G, Trichet V, Layrolle P, Le Goff B, Blanchard F.Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. J Clin Med. 2019 Sep 26;8(10)
• El Jamal A, Briolay A, Mebarek S, Le Goff B, Blanchard F, Magne D, Brizuela L, Bougault C. Cytokine- and stretch-induced sphingosine1-phosphate production by enthesis cells could favor abnormal ossification in spondyloarthritis. J Bone Miner Res. 2019; in press
• Granchi D, Ciapetti G, Gómez-Barrena E, Rojewski M, Rosset P, Layrolle P, Spazzoli B, Donati DM, Baldini N. Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow-derived mesenchymal stromal cells. Cytotherapy. 2019 in press
• Danieau G, Morice S, Rédini F, Verrecchia F, Royer BB. New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies? Int J Mol Sci. 2019; 31;20.
• Vargas-Franco JW, Castaneda B, Gama A, Mueller CG, Heymann D, Rédini F, Lézot F. Genetically-achieved disturbances to the expression levels of TNFSF11 receptors modulate the effects of zoledronic acid on growing mouse skeletons. Biochem Pharmacol. 2019; 28;168:133-148.
• Marino S, de Ridder D, Bishop RT, Renema N, Ponzetti M, Sophocleous A, Capulli M, Aljeffery A, Carrasco G, Gens MD, Khogeer A, Ralston SH, Gertsch J, Lamoureux F, Heymann D, Rucci N, Idris AI. Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. EBioMedicine. 2019;44:452-466
• Sanz M, Dahlin C, Apatzidou D, Artzi Z, Bozic D, Calciolari E, De Bruyn H, Dommisch H, Donos N, Eickholz P, Ellingsen JE, Haugen HJ, Herrera D, Lambert F, Layrolle P, Montero E, Mustafa K, Omar O, Schliephake H. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol. 2019;46, 21:82-91.
• David E, Cagnol S, Goujon JY, Egorov M, Taurelle J, Benesteau C, Morandeau L, Moal C, Sicard M, Pairel S, Heymann D, Redini F, Gouin F, Le Bot R. 12b80 - Hydroxybisphosphonate Linked Doxorubicin: Bone Targeted Strategy for Treatment of Osteosarcoma. Bioconjug Chem. 2019;30:1665-1676.
• Quillard T. Calcification associates with transcriptomic signatures related to plaque stability in carotid arteries. Atherosclerosis. 2019; S0021-9150(19)31374-7
• Danvin A, Quillard T, Espitia O, Charrier C, Guyomarch B, Gouëffic Y, Maurel B. Impact of Femoral Ossification on Local and Systemic Cardiovascular Patients' Condition. Ann Vasc Surg. 2019.12 S0890-5096(19)30397-8.
• Humbert P, M Brennan MA, Davison N, Rosset P, Trichet V, Blanchard F, Layrolle P. Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration. Front Imunol 2019. 2;10:663
• Leveque X, Hochane M, Geraldo F, Dumont S, Gratas C, Oliver L, Gaignier C, Trichet V, Layrolle P, Heymann D, Herault O, Vallette FM, Olivier C. Low-dose pesticide mixture induces accelerated mesenchymal stem cells aging in vitro. . Stem Cells. 2019;37:1083-1094
• Rojewski MT, Lotfi R, Gjerde C, Mustafa K, Veronesi E, Ahmed AB, Wiesneth M, Körper S, Sensebé L, Layrolle P, Hellem S, Schrezenmeier H. Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data.Cytotherapy. 2019;21:468-482
• Najm A, Blanchard F, Goff BL. Micro-RNAs in inflammatory arthritis: from physiopathology to diagnosis, prognosis and therapeutic opportunities. Biochem Pharmacol. 2019;165:134-144
• Bertin H, Guilho R, Brion R, Amiaud J, Battaglia S, Moreau A, Brouchet-Gomez A, Longis J, Piot B, Heymann D, Corre P, Rédini F. Jaw osteosarcoma models in mice: first description. J Transl Med. 2019. 27;17:56
• Vallette FM, Olivier C, Lézot F, Oliver L, Cochonneau D, Lalier L, Cartron PF, Heymann D. Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer. Biochem Pharmacol. 2019 Apr;162:169-176.
• Moukengue B, Amiaud J, Jacques C, Charrier C, Ory B, Lamoureux F. Analysis of mRNA, miRNA, and DNA in Bone Cells by RT-qPCR and In Situ Hybridization. Methods Mol Biol. 2019;1914:169-196.
• Jacques C, Renema N, Ory B, Walkley CR, Grigoriadis AE, Heymann D. Murine Models of Bone Sarcomas. Methods Mol Biol. 2019;1914:331-342.
• Arruda DC, Gonzalez IJ, Finet S, Cordova L, Trichet V, Andrade GF, Hoffmann C, Bigey P, de Almeida Macedo WA, Da Silva Cunha A Jr, Malachias de Souza A, Escriou V. Modifying internal organization and surface morphology of siRNA lipoplexes by sodium alginate addition for efficient siRNA delivery. J Colloid Interface Sci. 2019 14;540:342-353.
• Roulet S, Le Nail LR, Vaz G, Babinet A, Dumaine V, Sallot A, Rosset P. Free fillet lower leg flap for coverage after hemipelvectomy or hip disarticulation. Orthop Traumatol Surg Res. 2019;105:47-54
• Hoornaert A, Maazouz Y, Pastorino D, Aparicio C, De Pinieux G, Fellah BH, Ginebra MP, Layrolle P. Vertical bone regeneration with synthetic biomimetic calcium phosphate onto the calvaria of rats. Tissue Eng Part C Methods. 2019 Jan;25:1-11
• Najm A, le Goff B, Venet G, Garraud T, Amiaud J, Biha N, Charrier C, Touchais S, Crenn V, Blanchard F, Krenn V.IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis. Joint Bone Spine. 2019;86:77-81

2018

• Georges S, Calleja LR, Jacques C, Lavaud M, Moukengue B, Lecanda F, Quillard T, Gabriel MT, Cartron PF, Baud'huin M, Lamoureux F, Heymann D, Ory B. Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma. Oncotarget. 2018;9:35726-35741.
• Navet B, Vargas-Franco JW, Gama A, Amiaud J, Choi Y, Yagita H, Mueller CG, Rédini F, Heymann D, Castaneda B, Lézot F.Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups. J Clin Med. 2018. 8;7.
• Navet B, Ando K, Vargas-Franco JW, Brion R, Amiaud J, Mori K, Yagita H, Mueller CG, Verrecchia F, Dumars C, Heymann MF, Heymann D, Lézot F. The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases. Cancers (Basel). 2018. 24;10.
• Besio R, Maruelli S, Battaglia S, Leoni L, Villani S, Layrolle P, Rossi A, Trichet V, Forlino A. Early Fracture Healing is Delayed in the Col1a2+/G610C Osteogenesis Imperfecta Murine Model. Calcif Tissue Int. 103:653-662
• Guiho R, Biteau K, Grisendi G, Chatelais M, Brion R, Taurelle J, Renault S, Heymann D, Dominici M, Redini F. In vitro and in vivo discrepancy in inducing apoptosis by mesenchymal stromal cells delivering membrane-bound tumor necrosis factor-related apoptosis inducing ligand in osteosarcoma pre-clinical models. Cytotherapy. S1465-3249 30555-3.
• Gjerde C, Mustafa K, Hellem S, Rojewski M, Gjengedal H, Yassin MA, Feng X, Skaale S, Berge T, Rosen A, Shi XQ, Ahmed AB, Gjertsen BT, Schrezenmeier H, Layrolle P. Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Res Ther. 2018;9:21
• Jacques C, Renema N, Lezot F, Ory B, Walkley CR, Grigoriadis AE, Heymann D. Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations. J Bone Oncol. 2018 21;12:7-13.
• De Ridder D, Marino S, Bishop RT, Renema N, Chenu C, Heymann D, Idris AI. Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. Sci Rep. 2018. 2;8:6877. doi: 10.1038/s41598-018-25290-2.
• Verrecchia F, Rédini F. Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment. Front Oncol. 2018 30;8:133
• Gómez-Barrena E, Rosset P, Gebhard F, Hernigou P, Baldini N, Rouard H, Sensebé L, Gonzalo-Daganzo RM, Giordano R, Padilla-Eguiluz N, García-Rey E, Cordero-Ampuero J, Rubio-Suárez JC, Stanovici J, Ehrnthaller C, Huber-Lang M, Flouzat-Lachaniette CH, Chevallier N, Donati DM, Ciapetti G, Fleury S, Fernandez MN, Cabrera JR, Avendaño-Solá C, Montemurro T, Panaitescu C, Veronesi E, Rojewski MT, Lotfi R, Dominici M, Schrezenmeier H, Layrolle P. Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial. Biomaterials. 2018 S0142-9612 30205-9
• Steenman M, Espitia O, Maurel B, Guyomarch B, Heymann MF, Pistorius MA, Ory B, Heymann D, Houlgatte R, Gouëffic Y, Quillard T. Identification of genomic differences among peripheral arterial beds in atherosclerotic and healthy arteries. Sci Rep. 2018 2;8:3940.
• Le Nail LR, Brennan M, Rosset P, Deschaseaux F, Piloquet P, Pichon O, Le Caignec C, Crenn V, Layrolle P, Hérault O, De Pinieux G, Trichet V. Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma. Int J Mol Sci. 2018. 1;19.
• Garraud T, Harel M, Boutet MA, Le Goff B, Blanchard F. The enigmatic role of IL-38 in inflammatory diseases. Cytokine Growth Factor Rev. 2018 39:26-35
• Martin Thomé H, Bourdin D, Strube N, Saffarzadeh A, Morlock JF, Campard G, Evanno C, Hoornaert A, Layrolle P. Clinical evaluation of a new synthetic resorbable dental membrane: a case series study. J Oral Implantol. 2018 ;44:138-145
• Vargas-Franco JW, Castaneda B, Rédiní F, Gómez DF, Heymann D, Lézot F. Paradoxical side effects of bisphosphonates on the skeleton: what do we know and what can we do? J Cell Physiol. 2018 233:5696-5715.
• Talbot J, Brion R, Lamora A, Mullard M, Morice S, Heymann D, Verrecchia F. Connexin43 Intercellular Communication Drives the Early Differentiation of Human Bone Marrow Stromal Cells into Osteoblasts. J Cell Physiol. 2018. 233:946-957.
• Chalopin A, Tellez-Gabriel M, Brown HK, Vallette F, Heymann MF, Gouin F, Heymann D. Isolation of circulating tumor cells in a preclinical model of osteosarcoma: Effect of chemotherapy. J Bone Oncol. 2018 Jul 26;12:83-90.
• Espitia O, Chatelais M, Steenman M, Charrier C, Maurel B, Georges S, Houlgatte R, Verrecchia F, Ory B, Lamoureux F, Heymann D, Gouëffic Y, Quillard T. Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification. PLoS One. 2018 Jan 26;13 e0191976

2017

• Brown HK, Schiavone K, Gouin F, Heymann MF, Heymann D.Biology of Bone Sarcomas and New Therapeutic Developments.Calcif Tissue Int. 2017 386:189-195
• Heymann MF, Lézot F, Heymann D. The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. Cell Immunol. 2017 10.011
• Crenn V, Biteau K, Amiaud J, Dumars C, Guiho R, Vidal L, Nail LL, Heymann D, Moreau A, Gouin F, Redini F. Bone microenvironment has an influence on the histological response of osteosarcoma to chemotherapy: retrospective analysis and preclinical modeling. . Am J Cancer Res. 2017 1;7:2333-2349. eCollection 2017.
• Gaspar N, Occean BV, Pacquement H, Bompas E, Bouvier C, Brisse HJ, Castex MP, Cheurfa N, Corradini N, Delaye J, Entz-Werlé N, Gentet JC, Italiano A, Lervat C, Marec-Berard P, Mascard E, Redini F, Saumet L, Schmitt C, Tabone MD, Verite-Goulard C, Le Deley MC, Piperno-Neumann S, Brugieres L; SFCE (Société Française des Cancers de l'Enfant et l'adolescent); GSF-GETO (Groupe Sarcome Français); UNICANCER sarcoma group.Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.Eur J Cancer. 2017 Nov 27;88:57-66.
• Voissiere A, Weber V, Gerard Y, Rédini F, Raes F, Chezal JM, Degoul F, Peyrode C, Miot-Noirault E. Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept. Oncotarget. 2017 Sep 27;8:95824-95840.
• Darrieutort-Laffite C, Blanchard F, Le Goff B. Calcific tendonitis of the rotator cuff: from formation to resorption. Joint Bone Spine. 2017 doi: 10.1016/j.jbspin.2017.10.004.
• Brennan MA, Renaud A, Guilloton F, Mebarki M, Trichet V, Sensebé L, Deschaseaux F, Chevallier N, Layrolle P. Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue-Compared with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions. Stem Cells Transl Med. 2017 6:2160-2172.
• Gomez-Brouchet A, Illac C, Gilhodes J, Bouvier C, Aubert S, Guinebretiere JM, Marie B, Larousserie F, Entz-Werlé N, de Pinieux G, Filleron T, Minard V, Minville V, Mascard E, Gouin F, Jimenez M, Ledeley MC, Piperno-Neumann S, Brugieres L, Rédini F. CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial. Oncoimmunology. 2017 Aug 24;6:e1331193
• Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B. Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics. Hypoxia (Auckl). 2017 Mar 15;5:11
• Freeman FE, Schiavi J, Brennan MA, Owens P, Layrolle P, McNamara L. Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human MSCs. Tissue Eng Part A. 2017. 23:1466-1478.
• Miladi I, Vivier M, Dauplat MM, Chatard M, Besse S, Vidal A, Chassain K, Jean B, Forestier C, Chezal JM, Rédini F, Degoul F, Miot-Noirault E. Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma. Cancer Chemother Pharmacol. 2017;80:517-526.
• Bougault C, El Jamal A, Briolay A, Mebarek S, Boutet MA, Garraud T, Le Goff B, Blanchard F, Magne D, Brizuela L. Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. Bone, 103:150-158.
• Boutet MA, Blanchard F, Le Goff B. Response to: 'Does IL-38 act on macrophages and/or dendritic cells in arthritis?' by Jiang et al. Ann Rheum Dis. 2017; sous presse
• Vent PA, Kaladji A, Davaine JM, Guyomarch B, Chaillou P, Costargent A, Quillard T, Gouëffic Y. Bare Metal Versus Paclitaxel-Eluting Stents for Long Femoropopliteal Lesions: Prospective Cohorts Comparison Using a Propensity Score-Matched Analysis. Ann Vasc Surg. 2017;43:166-175.
• Mebarki M, Coquelin L, Layrolle P, Battaglia S, Tossou M, Hernigou P, Rouard H, Chevallier N. Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation. Acta Biomater. 2017, 1;59:94-107.
• Granchi D, Gómez-Barrena E, Rojewski M, Rosset P, Layrolle P, Spazzoli B, Donati DM, Ciapetti G. Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach. Stem Cells Int. 2017;2017:3674045.
• Sojod B, Chateau D, Mueller CG, Babajko S, Berdal A, Lézot F, Castaneda B. RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model. Front Physiol. 2017; 24;8:338.
• Boutet MA, Najm A, Bart G, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F, Le Goff B. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. 2017; 76:1304-1312.
• Niaudet C, Bonnaud S, Guillonneau M, Gouard S, Gaugler MH, Dutoit S, Ripoche N, Dubois N, Trichet V, Corre I, Paris F. Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis. Cell Signal. 2017 May;33:10-21
• Aubin GG, Baud'huin M, Lavigne JP, Brion R, Gouin F, Lepelletier D, Jacqueline C, Heymann D, Asehnoune K, Corvec S. Interaction of Cutibacterium (formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development. Sci Rep. 2017;7:42918.
• Laurent R, Nallet A, de Billy B, Obert L, Nicod L, Meyer C, Layrolle P, Zwetyenga N, Gindraux F. Fresh and in vitro osteodifferentiated human amniotic membrane, alone or associated with an additional scaffold, does not induce ectopic bone formation in Balb/c mice. Cell Tissue Bank. 2017;18:17-25
• Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23;121:31-42.
• Tellez-Gabriel M, Charrier C, Brounais-Le Royer B, Mullard M, Brown HK, Verrecchia F, Heymann D. Analysis of gap junctional intercellular communications using a dielectrophoresis-based microchip. Eur J Cell Biol. 2017;96:110-118.
• Hochane M, Trichet V, Pecqueur C, Avril P, Oliver L, Denis J, Brion R, Amiaud J, Pineau A, Naveilhan P, Heymann D, Vallette FM, Olivier C. Low-dose pesticide mixture induces senescence in normal mesenchymal stem cells (MSC) and promotes tumorigenic phenotype in premalignant MSC. Stem Cells. 2017;35:800-811.
• Chemel M, Brion R, Segaliny AI, Lamora A, Charrier C, Brulin B, Maugars Y, Le Goff B, Heymann D, Verrecchia F. Bone Morphogenetic Protein 2 and Transforming Growth Factor 1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts. Am J Pathol. 2017;187:156-162
• De Seta D, Torres R, Russo FY, Ferrary E, Kazmitcheff G, Heymann D, Amiaud J, Sterkers O, Bernardeschi D, Nguyen Y. Damage to inner ear structure during cochlear implantation: Correlation between insertion force and radio-histological findings in temporal bone specimens. Hear Res. 2017;344:90-97.
• Nasr B, Kaladji A, Vent PA, Chaillou P, Costargent A, Quillard T, Gouëffic Y. Long-term Results of Common Femoral Artery Stenting. Ann Vasc Surg. 2017 Jan;38:e1. doi: 10.1016/j.avsg.2016.07.004.

2016

• Jacques C, Calleja LR, Baud'huin M, Quillard T, Heymann D, Lamoureux F, Ory B. miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors. Oncotarget. 2016; 23;7:54503-54514.
• Tellez-Gabriel M, Ory B, Lamoureux F, Heymann MF, Heymann D. Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis. Int J Mol Sci. 2016; 20;17.
• Dumars C, Ngyuen JM, Gaultier A, Lanel R, Corradini N, Gouin F, Heymann D, Heymann MF. Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma. Oncotarget. 2016 29;7:78343-78354.
• Camuzard O, Santucci-Darmanin S, Breuil V, Cros C, Gritsaenko T, Pagnotta S, Cailleteau L, Battaglia S, Panaïa-Ferrari P, Heymann D, Carle GF, Pierrefite-Carle V. Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female. Oncotarget. 2016 sous presse
• Chiron D, Bellanger C, Papin A, Tessoulin B, Dousset C, Maiga S, Moreau A, Esbelin J, Trichet V, Chen-Kiang S, Moreau P, Touzeau C, Le Gouill S, Amiot M, Pellat-Deceunynck C. Microenvironment-dependent proliferation and mitochondrial priming loss in mantle cell lymphoma is overcome by anti-CD20. Blood. 2016 sous presse
• Lambert F, Bacevic M, Layrolle P, Schüpbach P, Drion P, Rompen E. Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites. Clin Oral Implants Res. 2016
• De Seta D, Mancini P, Russo FY, Torres R, Mosnier I, Bensimon JL, De Seta E, Heymann D, Sterkers O, Bernardeschi D, Nguyen Y. 3D curved multiplanar cone beam CT reconstruction for intracochlear position assessment of straight electrodes array. A temporal bone and clinical study. Acta Otorhinolaryngol Ital. 2016; 36:499-505
• Peyrode C, Weber V, Voissière A, Maisonial-Besset A, Vidal A, Auzeloux P, Gaumet V, Borel M, Dauplat MM, Quintana M, Degoul F, Redini F, Chezal JM, Miot-Noirault E. Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept. Mol Cancer Ther. 2016;;15:2575-2585.
• Corradini N, Dagorne L, Retailleau M, Rédini F, Sudour-Bonnange H, Gofti-Laroche L, Le Rhun A, Gaspar N. Which approach of therapeutic education (TE) for adolescents and young adults with cancer? Experience from the TE working group of "Go-AJA".  Bull Cancer. 2016. 103:966-978.
• Kager L, Whelan J, Dirksen U, Hassan B, Anninga J, Bennister L, Bovée JV, Brennan B, Broto JM, Brugières L, Cleton-Jansen AM, Copland C, Dutour A, Fagioli F, Ferrari S, Fiocco M, Fleuren E, Gaspar N, Gelderblom H, Gerrand C, Gerß J, Gonzato O, van der Graaf W, Hecker-Nolting S, Herrero-Martín D, Klco-Brosius S, Kovar H, Ladenstein R, Lancia C, LeDeley MC, McCabe MG, Metzler M, Myklebost O, Nathrath M, Picci P, Potratz J, Redini F, Richter GH, Reinke D, Rutkowski P, Scotlandi K, Strauss S, Thomas D, Tirado OM, Tirode F, Vassal G, Bielack SS. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report. Clin Sarcoma Res. 2016 Mar 16;6:3.
• Espitia O, Dréno B, Cassagnau E, Didier Q, Quillard T, Nicol C, Le Bouch Y, Planchon B, Pistorius MA. Exercise-Induced Vasculitis: A Review with Illustrated Cases. Am J Clin Dermatol. 2016;17:635-642. Review.
• Lamora A, Talbot J, Mullard M, Brounais-Le Royer B, Redini F, Verrecchia F. TGF- Signaling in Bone Remodeling and Osteosarcoma Progression. J Clin Med. 2016 3;5. pii: E96. review
• Michel L, Farge D, Baraut J, Marjanovic Z, Jean-Louis F, Porcher R, Grigore EI, Deligny C, Romijn F, Arruda LC, van Pelt J, Levarht N, Verrecchia F, van Laar JM.Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients. Bone Marrow Transplant. 2016;51:1146-9.
• Carapito R, Goldenberg A, Paul N, Pichot A, David A, Hamel A, Dumant-Forest C, Leroux J, Ory B, Isidor B, Bahram S. Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. Eur J Hum Genet. 2016;24:1746-1751.
• Guiho R, Biteau K, Grisendi G, Taurelle J, Chatelais M, Gantier M, Heymann D, Dominici M, Redini F. TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models. Int J Cancer. 2016; 139:2802-2811
• Renema N, Navet B, Heymann MF, Lezot F, Heymann D. RANK-RANKL signalling in cancer. Biosci Rep. 2016; 36-4
• Pohin M, Guesdon W, Mekouo AA, Rabeony H, Paris I, Atanassov H, Favot L, Mcheik J, Bernard FX, Richards CD, Amiaud J, Blanchard F, Lecron JC, Morel F, Jégou JF. Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation.. Eur J Immunol. 2016;46:1737-51
• Brulefert K, Córdova LA, Brulin B, Faucon A, Hulin P, Nedellec S, Gouin F, Passuti N, Ishow E, Heymann D. Pro-osteoclastic In Vitro Effect of Polyethylene-like Nanoparticles: Involvement in the Pathogenesis of Implant Aseptic Loosening. J Biomed Mater Res A. 2016;104:2649-57
• Córdova LA, Guilbaud F, Amiaud J, Battaglia S, Charrier C, Lezot F, Piot B, Redini F, Heymann D. Severe compromise of preosteoblasts in a surgical mouse model of bisphosphonate-associated osteonecrosis of the jaw.. J Craniomaxillofac Surg. 2016;44:1387-94
• Hoornaert A, d'Arros C, Heymann MF, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomed Mater. 2016;10;11:045012.
• Piperno-Neumann S, Le Deley MC, Rédini F, Pacquement H, Marec-Bérard P, Petit P, Brisse H, Lervat C, Gentet JC, Entz-Werlé N, Italiano A, Corradini N, Bompas E, Penel N, Tabone MD, Gomez-Brouchet A, Guinebretière JM, Mascard E, Gouin F, Chevance A, Bonnet N, Blay JY, Brugières L; Sarcoma Group of UNICANCER; French Society of Pediatric Oncology (SFCE); French Sarcoma Group (GSF-GETO). Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol. 2016; 17:1070-80
• Gabriel MT, Calleja LR, Chalopin A, Ory B, Heymann D. Circulating Tumor Cells: A Review of Non-EpCAM-Based Approaches for Cell Enrichment and Isolation. Clin Chem. 2016;62:571-81
• Stanovici J, Le Nail LR, Brennan MA, Vidal L, Trichet V, Rosset P, Layrolle P. Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery.Curr Res Transl Med. 2016;64:83-90. revue
• Tellez-Gabriel M, Brown HK, Young R, Heymann MF, Heymann D. The Challenges of Detecting Circulating Tumor Cells in Sarcoma. Front Oncol. 2016.7;6:202. Revue.
• Baud'huin M, Lamoureux F, Jacques C, Rodriguez Calleja L, Quillard T, Charrier C, Amiaud J, Berreur M, Brounais-LeRoyer B, Owen R, Reilly GC, Bradner JE, Heymann D, Ory B. Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis. Bone. 2016. 23;94:10-21.
• Jacques C, Lamoureux F, Baud'huin M, Calleja LR, Quillard T, Amiaud J, Tirode F, Rédini F, Bradner JE, Heymann D, Ory B. Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1. Oncotarget. 2016. 26;7:24125-40
• Ory B, Baud'huin M, Verrecchia F, Brounais-Le Royer B, Quillard T, Amiaud J, Battaglia S, Heymann D, Redini F, Lamoureux F. Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression. Clin Cancer Res. 2016; 15;22:2520-33
• Rodriguez Calleja L, Jacques C, Lamoureux F, Baud'huin M, Tellez Gabriel M, Quillard T, Sahay D, Perrot P, Amiaud J, Charrier C, Brion R, Lecanda F, Verrecchia F, Heymann D, Ellisen LW, Ory B. Np63 Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGF-Induced Metastasis. Cancer Res. 2016; 1;76:3236-51
• Flanagan-Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Haskins M, Blanchard F, Steet R. Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res. 2016;31:535-48.
• Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O. The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget. 2016; 23;7:8613-24
• Boutet MA, Bart G, Penhoat M, Amiaud J, Brulin B, Charrier C, Morel F, Lecron JC, Rolli-Derkinderen M, Bourreille A, Vigne S, Gabay C, Palmer G, Le Goff B, Blanchard F. Distinct expression of interleukin (IL)-36, and , their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease.Clin Exp Immunol. 2016; 184:159-73.
• Biteau K, Guiho R, Chatelais M, Taurelle J, Chesneau J, Corradini N, Heymann D, Redini F. L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer. Am J Cancer Res. 2016.15;6:677-89.
• Gabriel MT, Calleja LR, Chalopin A, Ory B, Heymann D. Circulating Tumor Cells: A Review of Non-EpCAM-Based Approaches for Cell Enrichment and Isolation.Clin Chem. 2016;62:571-81.
• Davaine JM, Quillard T, Chatelais M, Guilbaud F, Brion R, Guyomarch B, Brennan MÁ, Heymann D, Heymann MF, Gouëffic Y. Bone Like Arterial Calcification in Femoral Atherosclerotic Lesions: Prevalence and Role of Osteoprotegerin and Pericytes. Eur J Vasc Endovasc Surg. 2016;51:259-67.
• Heymann D, Ruiz-Velasco C, Chesneau J, Ratiskol J, Sinquin C, Colliec-Jouault S.Anti-Metastatic Properties of a Marine Bacterial Exopolysaccharide-Based Derivative Designed to Mimic Glycosaminoglycans.  Molecules. 2016. 4;21:309
• Avril P, Duteille F, Ridel P, Heymann M-F, De Pinieux G, Gouin F, Rédini F, Blanchard F, Heymann D, Trichet V, Perrot P. Opposite Effects of Soluble Factors Secreted by Adipose Tissue on Proliferating and Quiescent Osteosarcoma Cells. Plastic and Reconstructive Surgery, 2016;137:865-75